Curative effect of rosuvastatin and atorvastatin in elderly hyperlipoidemia patients
Abstract：Objective To compare the efficacy and safety of rosuvastatin and atorvastatin in elderly hyperlipoidemia patients .Methods One hundred and twenty-eight elderly phyperlipoidemia pa-tients who visited our department from from May 2012 to December 2012 were randomly divided into rosuvastatin treatment group (n=64) and atorvastatin treatment group (n=64) .Patients in rosuvastatin treatment group were treated with rosuvastatin (5 mg/d) and those in atorvastatin treatment group were treated with atorvastatin (10 mg/d) for 8 weeks .Primary hyperlipoidemia received conventional therapy with anti-hyperlipoidemia drugs withdrawn for 2 weeks in order to accurately assess the curative effect of rosuvastatin and atorvastatin .Results No significant difference was found in serum levels of TC ,LDL-C and TG ,although they were lower in rosuvas-tatin treatment group than in atorvastatin treatment group after 8-week treatment (25 .9% vs 22.6% ,33 .7% vs 31 .4% ,13 .5% vs 12 .1% ,P>0 .05) .The serum HDL-C level was significantly higher in rosuvastatin treatment group than in atorvastatin treatment group (9 .7% vs 3 .2% ,P<0 .05) .The drug dependence was good in two groups with no adverse event .Conclusion The effi-ciency and safety of rosuvastatin (5 mg/d) and atorvastatin (10 mg/d) are similar in reducing the serum levels of TC ,TG ,LDL-C ,and rosuvastatin can increase the serum HDL-C level in elderly hyperlipoidemia patients .
Keywords：hyperlipidemiasantilipemic agentshydroxymethylglutaryl-CoA reductase inhibitors
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 605-607 )