Effect of ischemic postconditioning on prognosis in acute myocardial infarction patients
Abstract：Objective To study whether ischemic postconditioning can effectively reduce ischemia/reperfusion (I/R)injury in acute myocardial infarction (AMI)patients .Methods Forty-two AMI patients admitted to our hospital were randomly divided into control group (n=22) and ischemic postconditioning group (n=20) .CK-MB value and average area under CK-MB curve were meas-ured before and 2 h ,1 ,2 ,3 days after PCI .Serum levels of CRP ,MDA and SOD were measured before and 2 h after PCI .ST segment falls on ECG were compared before and 24 h after PCI .Ma-lignant arrhythmia in the patients was recorded during their hospital stay .Results The peak CK-MB value ,average area under CK-MB curve ,serum levels of CRP and MDA were significantly lower while the serum SOD level was significantly higher in ischemic postconditioning group than in control group after PCI (P<0 .05 ,P<0 .01) .The ST segment fall was faster in ischemic post-conditioning group than in control group .Two patients in control group died of malignant ar-rhythmia .Conclusion Ischemic postconditioning can reduce the CK-MB release ,oxygen free radi-cal level ,inflammatory reaction ,I/R injury and restore coronary blood flow in AMI patients ,thus playing a role in protecting the heart .
Keywords：myocardial infarctionreperfusion injuryischemic preconditioningmyocardialcreatine kinaseMB formC-reactive proteinmalondialdehyde
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 584-587 )