Effect of loading dose rosuvastatin on PDCD4 expression in angina pectoris patients undergoing perioperative PCI
Abstract：Objective To study the effect of loading dose rosuvastatin on PDCD4 expression in un-stable angina pectoris patients undergoing perioperative PCI .Methods Ninety-two unstable angi-na pectoris patients admitted to our hospital were randomly divided into loading dose rosuvastatin treatment group and conventional dose rosuvastatin treatment group (46 in each group) .Patients in loading dose rosuvastatin treatment group were given 20 mg rosuvastatin daily before PCI and 10 mg rosuvastatin daily after PCI while those in conventional dose rosuvastatin treatment group were given 10 mg rosuvastatin daily before and after PCI .Circulating CD4 T lymphocytes were isolated using the magnetic cell sorting system .Expression of PDCD4 mRNA and protein was de-tected by RFQ-PCR and Western blot ,respectively .Serum TNF-αlevel was measured by ELISA . Results The expression levels of PDCD4 mRNA and protein were significantly lower in loading dose rosuvastatin treatment group after PCI than before PCI (P<0 .05) .The serum TNF-α level was significantlt higher in conventional dose rosuvastatin treatment group than in loading dose ro-suvastatin treatment group (14 .62 ± 2 .45 ng/L vs 9 .51 ± 1 .93 ng/L ,P< 0 .05) .Conclusion Loading dose rosuvastatin treatment can reduce the inflammatory reactions in myocardium after PCI by inhibiting the PDCD4 expression in CD4 T lymphocytes .
Keywords：anginaunstableCD4-positive T-lymphocytescell deathantilipemic agentshydroxy-methylglutaryl-CoA reductase inhibitors
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 564-567 )