A cross-sectional study on the correlation between blood inflammatory markers and periodontitis in middle-aged and elderly individuals
SONG Yuan-yuan
LI Xiao-fei
BI Ying-chun
Abstract：Objective The study aimed to investigate between inflammatory-related indicators derived from blood routine tests and periodontitis.Methods This study employed the data of participants aged over 45 from the National Health and Nutrition Examination Survey(NHANES)database of the United States from 2009 to 2014,and ultimately 5,617 cases were included.Weighted univariate and multivariate logistic regression,as well as restricted cubic spline regression,were employed to explore the relationship between CBC-derived inflammatory markers and periodontitis.Results Logistic regression analysis revealed showed that,without adjusting for covariates,systemic inflammatory response index(SIRI),systemic immune-inflammation index(SII),neutrophil-to-lymphocyte ratio(NLR),and monocyte-to-lymphocyte ratio(MLR)were positively correlated with periodontitis.After adjusting for confounding variables,SIRI,SII,NLR,and MLR remained significantly associated with periodontitis(OR values were 1.14,1.03,1.10,and 2.60,respectively;P＜0.05).The fitted smooth curves revealed a linear positive correlation between SIRI,SII,MLR,and periodontitis(non-linear P＞0.05),while the relationship between NLR and periodontitis was non-linear(non-linear P＜0.05).Conclusion These findings demonstrate that SIRI,SII,NLR,and MLR are associated with an increased risk of periodontitis.These inflammatory indices serve as valuable reference markers for the prevention,diagnosis,and treatment of periodontitis.
Keywords：blood inflammatory indicesperiodontitisinflammationNational Health and Nutrition Examination Surveycross-sectional study
Publication Date：2025-05-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 176-180 )