Correlation between serum inflammatory and oxidative stress and periodontal parameters in elderly patients with type 2 diabetes mellitus complicated with periodontitis
LIU Su-fang
WANG Jun
WU Ying-hao
YUAN Shuai
Abstract：Objective To investigate the correlation between the levels of serum advanced glycation end products(AGE),c-reactive protein(CRP),malondialdehyde(MDA)and periodontal parameters in elderly patients with type 2 diabetes mellitus(T2DM)complicated with periodontitis.Methods 45 elderly patients with T2DM combined with periodontitis in our hospital from June 2021 to October 2022 were selected as T2DM periodontitis group,.45 healthy elderly patients with periodontitis were selected as control group,and 45 elderly patients with periodontitis were selected as simple periodontitis group.General data,periodontal parameters[probing depth(PD),sulcus bleeding index(SBI)]and serum factor indexes(AGE,CRP,MDA)of the enrolled patients were compared.The correlation between serum AGE,CRP,MDA levels and periodontal parameters was analyzed by Pearson.Results PD and SBI in simple periodontitis group and T2DM periodontitis group were higher than those in control group,and PD and SBI in T2DM periodontitis group were higher than those.in simple periodontitis group(P<0.05).The levels of serum AGE,CRP and MDA levels in simple periodontitis group and T2DM periodontitis group were higher than those in control group,and the levels of serum AGE,CRP and MDA levels in T2DM periodontitis group were higher than those in simple periodontitis group(P<0.05).Pearson correlation showed that serum AGE,CRP and PD were strongly correlated(r=0.611,P<0.001;r=0.646,P<0.001),serum MDA was moderately correlated with PD(r=0.554,P<0.001).Serum AGE was moderately correlated with SBI(r=0.575,P<0.001),and serum CRP,MDA and SBI were strongly correlated(r=0.691,P<0.001;r=0..689,P<0.001).Conclusions Serum AGE,CRP and MDA levels were significantly increased in elderly patients with T2DM and periodontitis,and the above indexes were positively correlated with periodontal parameters PD and SBI.
Keywords：ElderlyPeriodontitisType 2 diabetes mellitusPeriodontal parametersAdvanced glycation end productsC-reactive proteinmalondialdehyde
Publication Date：2024-01-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 21-25 )