The influence effect of bone metabolic drugs on osseointegration of titanium implants
ZHANG Shao-qing
HE Hui-xia
Abstract：Drugs affecting bone metabolism can be classified into two categories:anabolic and anti-catabolic bone-acting agents.Anabolic bone-acting agents include parathyroid hormone (PTH) peptides,simvastatin,prostaglandin EP4 receptor antagonist,vitamin D and strontium ranelate;Examples of the new therapies include DKK1-and anti-sclerostin antibodies.anti-catabolic bone-acting agents include compounds like calcitonin,biphosphonates,RANK/RANKL/OPG system and selective estrogen receptor modulators (SERM).Most of those agents have been first described in the treatment of osteoporosis,because the same bone remodeling process is the main target in both osseointegration and osteoporosis.
Keywords：bone metabolic drugstitanium implantsosseointagration
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 180-185 )