Effect of estrogen deficiency on the expression of HMGB1 in periapical lesions of rats
GUAN Xiao-yue
QIAN Hua
GUAN Yong-hui
Gulinuer·Awuti
Abstract：Objective:To study the effects of estrogen deficiency on the expression of HMGB1 in Periapical lesions of rats.Methods:Forty SD female rats were randomly divided into two groups:OVX group and SHAM group.All the rats were submitted to expose the pulp cavity of mandibular first molars.The rats were sacrificed on day 0,7,14,21 after the pulp cavity exposure.HE staining,enzyme histochemical staining and immunohistochemical staining were used to observe the bone destruction,the number of osteoclasts and the expression of HMGB1.Results:The alveolar bone loss area and the number of losteoclasts,HMGB1 positive cells in OVX group were higher than those in SHAM group.Conclusion:Estrogen deficiency increased the expression of HMGB 1 in rat's periapical lesions.
Keywords：Estrogen deficiencyapical periodontitisHMGB1
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 23-27 )