The establishment of humanized SCID-beige mouse model and the model of oral squamous cell carcinoma
REN Yi-peng
ZHANG Lei
SHI Yue-yi
BU Rong-fa
Abstract：Objective:To establish humanized SCID-beige mouse model and apply it to the establishment of oral squamous cell carcinoma model.Methods:A humanized SCID-beige mouse model was established by intraperitoneal injection of human peripheral blood lymphocytes.The level of humanized immunoglobulins was evaluated and the tumor bearing model was established by using the commonly used human tongue cancer cell line.Results:1、Humanized SCID-beige mouse model had a high level of human IgG;2、The common used human tongue cancer cell line TCA8113、SCC9 and SCC25 could be transplanted in the humanized SCID-beige mouse model successfully.Conclusion:SCID-beige mice could be used in the establishment of humanized mouse model,which could be used for the immune related research of oral squamous cell carcinoma.
Keywords：hu-PBL-SCID-beige micePBLTCA8113SCC9SCC25
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 349-352 )