Study on proteomics of rats with facial nerve clamp injury
LI Bo-han
E Ling-ling
XIE Xiao
LIU Hong-chen
Abstract：Objective:To investigate the differentially expressed proteins of facial nerve between normal rats and facial nerve crush injury rats.Methods:Facial nerve and crush injury nerve were selected as normal controls control group and experimental group respectively.After protein extraction,differentially expressed proteins were separated by two-dimensional gel electrophoresis (2-DE) and identified by MALDI-TOF/TOF.Statistical analysis of data was performed using SPSS 15.0 software package.Results:According to the proteomics study,there were 19 significant differences between the two groups,and the difference of 4 protein points was more than 20 times.The 4 proteins fell into 3 functional categories as follows:metabolism,information storage and transduction.Conclusion:The differentially expressed proteins of facial nerve between normal rats and facial nerve injury rats may be new targets for investigating the mechanisms of the effect of nerve injury.
Keywords：facial nerve injuryproteomicsdifferential protein
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 328-331,343 )