Study on the relationship between Treg level in peripheral blood and tumor microenvironment of patients with oral squamous cell carcinoma
SHI Yue-yi
REN Yi-peng
ZHANG Lei
BU Rong-fa
Abstract：Objective:o investigate the distribution of Treg immune cells in peripheral blood and tumor microenvironment of patients with oral squamous cell carcinoma (OSCC).Methods:30samples of primary OSCC cancer patients were analyzed with flow cytometry for Treg expression.Result:1.There was no significant difference in CD4+CD25highFoxP3+cells between the venous blood groups and control groups.2.The CD4+CD25highCD 127low cells in venous blood groups were higher than control groups.3.The proportion of CD3 l+Treg of Treg in OSCC was higher than control groups.4.There was Treg infiltration in local micro-environment of OSCC patients.Conclusion:OSCC patients with abnormal levels of Treg,we infer that the infiltration of Treg may inhibit the anti-tumor effects of anti-tumor factors in the whole body and local microenvironment.
Keywords：oral squamous cell carcinomaT-cell Infiltrationtumor micro-environment
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 77-81 )