Alveolar bone regeneration around immediate implants using an injectable nHAC/CSH loaded with autogenic dog Blood-Acquired mesenchymal progenitor cells
HAN Xue
LIU Hong-chen
WANG Dong-sheng
E Ling-ling
WU Xia
Zhou Wei
Abstract：Objective:The aim of the study was to assess the new bone formation around immediate dental implants using nHAC/CSH loaded with dog blood-acquired mesenchymal progenitor cells (dBMPC) in a canine model. Methods: Dog blood-acquired mesenchymal progenitor cells (dBMPCs) were isolated from peripheral blood of healthy adult dogs. Four healthy mongrel dogs were used in this study. The alveolar bone defects around immediate implants of dogs were created. Each defect was randomly assigned to one of the following three groups:(1) no materials (controls); (2) injectable bone cement: nHAC/CSH; or (3) the injectable tissue engineered bone (ITB) group: nHAC/CSH- dBMPC; Methylene blue staining was used to examine the bone formation after 12 weeks. Results: The nHAC/CSH- dBMPC group showed significantly more bone-implant contact than either nHAC/CSH or control groups in the areas with peri-implant defects12 weeks after implantation. Conclusion: The results indicate that the ITB composed of nHAC/CSH and dBMPC may represent a useful strategy for the clinical reconstruction of bone defects around immediate implantation. However, further investigation is needed involving the use of human BMPC as well as possible use of seeding cells.
Keywords：bone tissue engineeringinjectablenHAC/CSHperipheral blood
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 144-148 )