Progress of research on Meniere's disease from an immunological perspective
ZHANG Yiling
ZHOU Ziyi
GUO Jia
HU Yuquan
WANG Qin
Abstract：Meniere's disease(MD)is an inner ear disorder with a complex etiology and high disease heterogeneity.Recent studies suggest that immune system dysfunction may play a critical role in its pathogenesis and progression.This review summarizes the immune mechanisms underlying MD,with a focus on its comorbid autoimmune diseases,and provides a comprehensive overview of the latest findings in immune cells,cytokines,and proteomic studies.Dysregulated innate and adaptive immune responses,along with abnormal expression of related immune mediators,contribute to the disruption of the inner ear immune microenvironment.In addition,proteomic analyses have identified a series of MD-related biomarkers,which may facilitate disease diagnosis,staging and the development of personalized therapeutic strategies.In conclusion,the immunological basis of MD is gradually being elucidated,suggesting that it may represent a subtype of autoimmune-related disorders.Targeted interventions aimed at immune pathways may provide more precise therapeutic approaches for MD patients in the future.
Keywords：Meniere's diseaseautoimmunitycytokinesproteomics
Publication Date：2026-02-20
Online Publishing Date：2026-03-13(First online date of this platform, not the publication date of the document)
Pages：5( 154-158 )