Progress of Research on Correlation between Microbiota and Pathogenesis of Middle Ear Cholesteatoma
LIU Xiaoxiao
YANG Runqin
LI Rui
WANG Wenyue
ZHA Dingjun
HAN Yu
Abstract：Middle ear cholesteatoma is a non-neoplastic tumor characterized by the abnormal proliferation of squamous epithelial cells in the middle ear,which invade the adjacent bone structures and cause extensive local tissue destruction.It can lead to various clinical manifestations such as ear discharge,hearing loss,tinnitus,peripheral facial paralysis,and vertigo.At present,the mechanism of its occurrence and development is yet to be fully elucidated.However,with continuous research and discoveries in microbiome,the relationship between pathogenesis and mechanism of local invasion in middle ear cholesteatoma and the microbiota has been gradually revealed.This is a review of this correlation.
Keywords：middle ear cholesteatomaflora16S rRNApathogenesis
Publication Date：2025-09-20
Online Publishing Date：2025-09-15(First online date of this platform, not the publication date of the document)
Pages：5( 800-804 )