Progress of Research on Non-Coding RNA in Middle Ear Cholesteatoma
WANG Jiantao
ZHU Qingwen
WANG Baoshan
Abstract：Middle ear cholesteatoma is a common disease in otolaryngology.In recent years,its clinical importance has become increasingly prominent.Data shows that the annual incidence rate of this disease is 10/100,000.Currently,there is no effective non-surgical treatment method in clinical practice,and the postoperative recurrence rate is as high as 40%.If not diagnosed and intervened in a timely manner,it can lead to various intracranial and extracranial complications.The pathogenesis research of cholesteatoma.formation focuses on cell proliferation,apoptosis,and bone destruction.Various non-coding RNAs have garnerd significant attention due to their pivotal roles in gene expression,cell cycle regulation,and disease pathogenesis and pro gression.Notably,research on microRNA,long non-coding RNA,and circular RNA has been particularly extensive.In this review,progress of research on the role of ncRNA in middle ear cholesteatoma is reviewed.
Keywords：middle ear cholesteatomanon-coding RNAmicroRNAcircRNAlncRNA
Publication Date：2025-07-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 597-602 )