Cochlear Structure and the Cochlear Implantation in Patients with Vestibular Aqueduct Syndrome
YU Changbin
ZHUANG Boxing
FU Zhenhao
ZUO Huijun
HONG Mengdi
CHEN Wei
YANG Shiming
Abstract：Objective To report findings on cochlear structure of and hearing prognosis after cochlear implantation patients with large vestibular aqueduct syndrome(LVAS).Methods Data from patients with enlarged vestibular aqueduct(n=69,78 ears)who underwent cochlear implantation in the Department of Otorhinolaryngology,General Hospital of Chinese People's Liberation Army,from January 2012 to June 2023 were retrospectively analyzed using the SPSS25.0 statistical software,including structure data and hearing results were.Results The combined endolymphatic sac and endolymphatic duct volume was positively correlated with the midpoint and outer diameters of the vestibular aqueduct(r=0.275 and 0.246;P=0.016 and 0.031),as well as fluctuating hearing loss events(r=0.355,P=0.002).The midpoint diameter of the vestibular aqueduct was also positively correlated with the diameter of the external orifice(r=0.711,P<0.001).This volume showed no correlation with ASNR extraction rate(P=0.100)or postoperative hearing threshold(P=0.335).The midpoint diameter of the vestibular aqueduct and the diameter of the external orifice showed no correlation with fluctuation of hearing loss events(P=0.310),ASNR extraction rate(P=0.239)or post-implantation hearing(P=0.326).Modini malformation was not correlated with fluctuating hearing loss events(P=0.295),but negatively with ASNR extraction rate(r=-0.272,P=0.018).Conclusion The diameter of the vestibular aqueduct is not correlated to characteristics of hearing development but to the size of endolymphatic sac and endolymphatic duct,which is correlated to characteristics of hearing development.Larger endolymphatic sac and endolymphatic duct volumes are linked to a greater possibility of fluctuating hearing loss,while smaller volumes are associated with greater possibility of extremely severe sensorineural hearing loss at birth.The pathogenesis of LVAS may involve imbalance of pressure regulation with increased endolymphatic sac volume.The vestibular aqueduct structure has little influence on post-implantation hearing.Postoperative residual hearing preservation may show differences between LVAS and non-LVAS patients.The rate of ASNR extraction in LVAS patients with Modini malformation is decreased.
Keywords：large vestibular aqueduct syndromeendolymphatic sac plus endolymphatic vessel volumevestibular aqueduct diameterartificial cochlea
Publication Date：2025-06-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 418-422 )