Advances of Pattern Recognition Receptor in Immune Responses in Otitis Media
CHEN Yingying
LIU Yang
ZHENG Tihua
ZHANG Xiaolin
ZHAO Hongchun
Abstract：Otitis media(OM)is associated with a high prevalence and a high incidence,and is a major global medical burden.Innate immune system,a key first line of defense in the middle ear,is activated primarily by pattern recognition receptors(PRRs)in response to pathogen-associated molecular patterns(PAMPs)on invading pathogens to cause an inflammatory response.This review examines the role of PRRs in OM pathogenesis,aiming to provide a theoretical foundation and new directions for the prevention and treatment of OM.
Keywords：otitis mediapattern recognition receptorinnate immune responsepathogenesis
Publication Date：2025-04-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 277-282 )