Correlation between Hearing Impairment and Use of Macrolide Antibiotics Based on FAERS Reports
FU Zhonghua
SHEN Qingli
ZHAO Chenglong
Abstract：Objective To determine the correlation between macrolide antibiotics usage and hearing impairment using the FDA Adverse Event Reporting System(FAERS).Methods The OpenVigil platform was used to search for FAERS reports of hearing impairment adverse reactions suspected to be linked to macrolides from January 2004 to January 2023.Reporting odds ratio(ROR),proportional reporting ratio(PRR)and Bayesian confidence neural network(BCPNN)were used to evaluate the correlation between macrolides and hearing impairment as well as differences among macrolids.Results The A total of 84,088 reports on macrolide-related hearing impairment were retrieved,involving azithromycin(n=428,2.34%),clarithromycin(n=415,10.84%)and erythromycin(n=64,1.56%).Hearing impairment was significantly correlated with azithromycin and clarithromycin(ROR=3.74 and 3.59,respectively),and weakly with erythromycin(ROR=1.28).All three drugs showed strong correlation to ototoxicity,bilateral deafness,sensorineural deafness and deafness.Conclusion This study shows an association between macrolide antibiotics and hearing impairment.Evaluation of ototoxicity adverse events is important in clinical practice to ensure safety medication use for patients.
Keywords：macrolides antibioticshearing impairmentototoxicityU.S.food and drug administration adverse event reporting system
Publication Date：2025-02-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 54-58 )