Correlation between Age-related Hearing Loss and Cognitive Dysfunction in Cdh23erl2/erl2 Mice
WU Yuancheng
TANG Lihuan
XIE Daoli
ZHENG Tihua
WANG Xiaowen
ZHENG Qingyin
LI Bo
Abstract：Objective To study the correlation between age-related hearing loss and cognitive dysfunction using the Erl2 mouse model.Methods Erl2 and CBA/CaJ mice were grouped based on age(2,4 and 8 months).Auditory brain stem responses(ABRs)were used to assess auditory function,and novel object recognition,the Y-maze and Morris water maze tests were used to assess cognitive function.Pearson analysis was used to determine correlation between age-related hearing loss and cognitive decline.Immunofluorescence assay was used to label neonatal neurons in the dentate gyrus of the hippocampus.Results ABR thresholds in Erl2 mice increased with age,showing age-related hearing loss,but not in CBA/CaJ mice.Compared with CBA/CaJ mice,novel object recognition,Y maze and Morris water maze measurements all decreased in 8-months-old Erl2 mice,but not in 2-and 4-months-old mice.There was a correlation between age-related hearing loss and cognitive decline in Erl2 mice.Immunofluorescence showed significantly lower numbers of neonatal neurons in the dentate gyrus region of the hippocampus in 8-month-old Erl2 mice than in CBA/CaJ mice.Conclusion There was a correlation between age-related hearing loss and cognitive decline in Erl2 mice.Reduced neuron regeneration in the dentate gyrus of hippocampus may be one of the pathologic mechanisms associated with age-related hearing loss and cognitive decline.
Keywords：age-related hearing losscognitive dysfunctionhippocampus
Publication Date：2024-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 989-995 )