Mendelian Randomization Study on Blood Lipids and Sudden Sensorineural Hearing Loss
PU Kunlin
QIU Yan
SONG Hongmei
Abstract：Objective To investigate the causal relationship between lipid levels(triglycerides,high-density lipoprotein,low-density lipoprotein,apolipoprotein A and apolipoprotein B)and Sudden sensorineural hearing loss(SSNHL)by Mendelian randomization.Methods Lipids indices from the UK Biobank(UKB)and genome-wide association study(GWAS,a FinnGen study)data concerning SSNHL were subjected to inverse variance weighted(IVW),MR-Egger regression,weighted median,weighted mode and simple mode analyses in a two-sample Mendelian randomization study.Results IVW showed that triglycerides(OR=0.991,95％CI:0.831-1.182,P=0.924),LDL-C(OR=1.067,95％CI:0.861-1.322,P=0.552),Apo B(OR=1.120,95％CI:0.928-1.352,P=0.235)were not significantly associated with the risk of SSNHL(P>0.05),whereas HDL-C(OR=0.822,95％CI:0.694-0.974,P=0.023)and Apo A(OR=0.821,95％CI:0.682-0.988,P=0.037)were(P<0.05).Conclusion The Mendelian randomization study results suggest that decreases of HDL-C and Apo A are potential risk factors for SSNHL.
Keywords：lipidsudden sensorineural hearing lossMendelian randomization
Publication Date：2024-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 950-954 )