Audiological Characteristics and Differential Expression lncRNA in Elderly Patients with Parkinson's Disease

MAO Haiting; JI Fei; ZHANG Jinqian; GAO Zhongbao; LI Zibo; LI Shibo; TANG Ruonan; WANG Miao; YIN Xi; TAO Anzhou

doi:10.3969/j.issn.1672-2922.2024.06.006

Abstract：Objective To report characteristics of mild to moderate age-related hearing loss in elderly patients with Parkinson's disease(PD)and expression of plasma lncRNA.Methods Fifteen patients with mild to moderate ARHL who visited the PLA General Hospital from January 2022 to May 2023 were included(13 PD and 2 non-PD patients).All 15 patients completed audiometry tests.Whole transcriptome RNA sequencing was completed in PD patients.Auditory characteristics and plasma lncRNA expression were analyzed based on the degree of hearing loss,gender and age.Results The average hearing threshold showed no significant difference between male and female patients(P>0.05),or between the 60-69 years and 70-79 years age groups(P>0.05).In PD patients,the detection of ABR waveⅤwas the highest and wave I the lowest,although there was no significant difference in the detection of wavesⅠ,ⅢandⅤamong patients of the same gender(P>0.05).In patients with PD,RNA-seq showed 472 differences in lncRNA expression between patients aged 70-79 years and those aged 60-69 years(upregulated in 239 and downregulated in 233);535 expression differences were noticed between female and male patients(upregulated in 458 and downregulated in 77);550 differences between patients mild hearing loss and those with moderate loss(upregulated in 107 and downregulated in 443);and 1115 differences between patients with moderate hearing loss and those with moderate-severe loss(upregulated in 226 and downregulated in 889).Conclusions While there is no significant difference in audiological characteristics among PD patients regarding their levels of hearing loss,gender and age,lncRNA expression in peripheral blood can vary and therefore can potentially be used as a biomarker for diagnosis of mild to moderate age-related hearing loss in elderly patients with PD.