A Meta-analysis of Real-world Association between Serum Lipid and Sudden Hearing Loss
ZHANG Yaming
LI Zhiyong
GUO Dandan
WANG Guanghui
Abstract：Objective To systematically evaluate the correlation between blood lipid levels and sudden hearing loss(SHL).Methods A standardized search of case-control studies on the correlation between lipid levels and SHL collected in major domestic and international databases was performed using a combination of subject terms,free words and keywords,with a search period from database creation to August 2022.Meta-analysis was performed using the RevMan 5.3 software.Results A total of 31 studies were included.Analysis showed that serum total cholesterol(TC),triglyceride(TG)and low-density lipoprotein cholesterol(LDL-C)levels were higher in the SHL group than in the control group(P＜0.05);whereas serum HDL-C levels were not significantly different(P＞0.05).Meta-regression analysis suggested that all or more factors including the time of publication of the included literature,geographical region,age of the study group,sample size and cardiovascular disease were important factors affecting the correlation between serum TC,TG and LDL-C and SHL(P＜0.05).Subgroup analysis showed that the correlation between serum TC,TG and LDL-C levels and SHL was significantly different in different geographical areas(P＜0.05).Conclusion Serum TC,TG and LDL-C levels may be associated with the development of SHL and are influenced by geographical factors.Identification of dyslipidemia facilitates the early assessment and management of SHL risks.
Keywords：blood lipidsudden deafnesssudden hearing lossMeta analysis
Publication Date：2024-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 790-797 )