Progress of Research on Hippo/Yap Signaling Pathway in Regulation of Auditory System
HAO Wenli
YU Chenjie
CHENG Cheng
LU Jie
QIU Yue
JI Xinya
QIAN Xiaoyun
GAO Xia
Abstract：The Hippo/Yap signaling pathway is extensively implicated in auditory system development,hearing injury repair,and auditory system disorders.The regulation of Yap during embryonic development may result in mor-phological and functional defects of the hearing organ.The Hippo/Yap signaling pathway is involved in processes relat-ed to hearing system injury and diseases by interacting with a wide range of signaling molecules,which are influenced by the JNK signaling pathway,the Wnt signaling system,and mechanical signal transduction.This review covers the de-velopment in Hippo/Yap signaling pathway research in regard to the auditory system,to hopefully provide novel ideas for understanding the molecular biological process and developing therapeutic therapies for various forms of hearing loss.
Keywords：Hippo/Yap signalinghearing lossHCs regenerationhearing protection
Publication Date：2024-08-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 661-665 )