Progress of Research on Eph/ephrin signaling pathway in otolaryngological diseases
HUANG Qiao
YIN Shihua
Abstract：Erythropoietin-producing hepatocellular receptors and their receptor-interacting proteins(Eph/ephrin),a receptor tyrosine kinase signaling pathway,are involved in multiple cellular pathophysiological and physiological mechanisms such as inflammation,cancer progression,tumor angiogenesis,intestinal environmental stability,immune response,tumor immunity,neural development,and inhibition of nerve regeneration after injury.Eph/ephrin signaling plays a core role in the development of auditory nerves,the formation of auditory system circuits and topological struc-tures,the development of chronic sinusitis,and the invasion,metastasis and treatment response in head and neck tumors.It may become a diagnostic indicator,a prognostic indicator,and an important therapeutic target in otolaryngological dis-eases.This study mainly reviews the roles of the Eph/ephrin signaling pathway in otolaryngological diseases.
Keywords：Erythropoietin-producing hepatocellular receptors and their receptor-interacting proteins(Eph/eph-rin)Auditory systemChronic rhinosinusitisHead and neck Tumor
Publication Date：2024-06-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 504-508 )