The Relationship between Bone Metabolism Indicators and Otolith Related Proteins in Patients with BPPV
WANG Boshen
SUN Haibo
TIAN Yu
JIN Jing
LENG Hui
Abstract：The formation,structure,and physiological metabolism of human bones and otoliths are similar.Ab-normal bone metabolism in osteoporosis(OP)has been extensively studied.Some studies on otoliths shedding in benign paroxysmal positional vertigo(BPPV)suggest a close correlation with human bone metabolism.Vitamin D and estrogen are important bone metabolism indicators in osteoporosis.Otolith related proteins in BPPV include Otoconin-90(OC90),Otolin-1,Plasma membrane calcium ATPase 2(PMCA2),Nicotinamide adenine dinucleotide phosphate phos-phate oxidase 3(NOx3,NADPH oxidase 3 for short),etc.Based on the close relationship between bone metabolism and vitamin D and estrogen,this article summarizes research on the correlation between bone metabolism indicators and oto-lith related proteins in BPPV,and discuss on the quantitative relationship,the role of vitamin D and estrogen in the oc-currence of BPPV and repeated otolith shedding,to provide new ideas and inspiration for future research on the mecha-nism by which bone metabolism influences otolith shedding in BPPV.
Keywords：benign paroxysmal positional vertigo(BPPV)bone metabolism indicatorsotolith related proteinsotolith shedding
Publication Date：2024-06-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 467-470 )