Progress of Research on Hydrogel for Local Drug Delivery to the Inner Ear
XIONG Haixia
DIAO Mingfang
Abstract：Hydrogel is generally composed of a three-dimensional network structure with strong hydrophilicity,which is a semi-solid aggregation gel with soft tissue characteristics.It can not only maintain a specific form,but also achieve diffusion and penetration of drug molecules from the gel matrix.Because of its unique network structure and high viscosity,it is more conducive to retention of drugs in the middle ear cavity.Compared with drug solutions,hydro-gel via intratympanic injection can reduce administration frequency and achieve sustained drug release.In this paper,we reviewed the classification,characteristics,efficacy and progress of research on hydrogels based local drug delivery sys-tems for inner ear drug administration.
Keywords：hydrogelinner ear deliverypoloxamer 407nanoparticles
Publication Date：2024-04-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 335-338 )