Research Progress On miRNA In Presbycusis
LI Ke
LI Tingting
CHANG Jing
WANG Jiaxin
ZHOU Bin
Abstract：Age-related hearing impairment(ARHI),also known as age-related deafness,is progressive,symmet-ric,irreversible bilateral sensorineural hearing loss.The development of age-related deafness is a multifactorial combina-tion of genetics,environmental exposures,health co-morbidities,and pathophysiological changes associated with aging.Degeneration of cochlear hair cells is one of the major causes of age-related deafness;however,the molecular mecha-nisms mediating apoptosis of cochlear hair cells are not fully understood.miRNAs play critical roles in important biolog-ical processes such as cell proliferation,metastasis,apoptosis,and aging.Currently,a large number of miRNAs have been shown to be closely associated with age-related deafness and potentially promising therapeutic targets.To better un-derstand and explore the role of miRNAs in age-related deafness and their potentials for innovative therapies,this article outlines important miRNAs associated with age-related deafness.
Keywords：presbycusisage-related hearing impairmentgenesmiRNAhair cells
Publication Date：2023-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 887-891 )