Expression of Cytokines in the Endolymphatic Sac in Patients with Meniere's Disease
HUANG Li
WANG Qin
HUANG Chao
ZHANG Zhiwen
LI Wei
LIU Wei
PENG Anquan
ZHOU Zhou
PAN Xueying
Abstract：Objectiv Immune mediated inflammatory changes in the endolymphatic sac(ES)may underlie the mechanism of Meniere's disease(MD).The aim of the present study was to study the role of expression of proinflamma-tory cytokines in the ES in patients with MD as potential mechanisms underlying MD.Methods Human ES tissue was collected from patients with unilateral MD and patients with acoustic neuroma(AN)during surgery.Immunohistochemi-cal techniques were used to detect expression of tumor necrosis factor-α(TNF-α)and interferon-y(IFN-γ).Results Posi-tive immunostaining of TNF-α was identified in the ES epithelium,as well as in subepithelial connective-tissue fibro-blasts,in all 9 patients with MD,with strong epithelial cells staining in 5 patients,moderate levels of staining in 3 pa-tients and weak staining in 1 patient.IFN-y immunoreactivity was seen in the epithelial lining of the ES in 7 out of the 9 patients,with strong staining in 4 and moderate staining in 3 patients.In contrast,in 10 ES specimens from patients with AN,only weak TNF-α staining of epithelial cells was seen in 4 and negative in 6,with no expression of IFN-γ.Conclu-sions Positive expression of TNF-α and IFN-γ in the ES in patients with MD provides direct evidence of increased im-munologic activities in the ES microenvironment in patients with unilateral MD,suggesting that local inflammatory re-sponses may be a mechanism for this disease.
Keywords：meniere's diseaseendolymphatic sactumor necrosis factor-αinterferon-y
Publication Date：2023-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 871-875 )