Protective Effects of Methylprednisolone Gel on Inner Ear against Noise Induced Deafness in Rats
SUN Haili
ZHANG Lichuan
YU Zhan
Abstract：Objective To investigate effects of intratympanic injection of methylprednisolone hyaluronic acid hy-drogel on hearing impairment caused by noise exposure in rats for its potential protective and therapeutic effects.Meth-ods Rats were randomly divided into a normal control group,a intratympanic methylprednisolone hyaluronic acid hydro-gel injection group,a noise exposure group and a noise exposure with intratympanic methylprednisolone hyaluronic acid hydrogel injection group.Auditory brainstem evoked potentials(ABRs)were measured and damage of hair cells ob-served using fluorescent staining laser confocal microscopy.Results Average ABR threshold was(35.1±9.3)dB SPL in the noise-exposure with intratympanic methylprednisolone injection group and(57.3±15.2)dB SPL in the noise-expo-sure only group(P＜0.01).Conclusion Intratympanic administration of methylprednisolone has evidently protective and therapeutic effects on cochlear hair cells,and provides a theoretical basis for the treatment of inner ear diseases.
Keywords：noise-induced deafnesstympanic injectionlocal administrationinner ear disease
Publication Date：2023-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 866-870 )