Research Progress on Molecular Etiology of Syndromes with Middle Ear Deformity
WU Xiedong
WANG Guojian
HUANG Shasha
SAI Na
HAN Dongyi
Abstract：Common causes of conductive deafness include otitis media,tympanic space occupying lesions,trau-ma,middle ear deformity and otosclerosis.Middle ear deformity and otosclerosis can be correlated with genetic factors.Abnormal embryonic development of middle ear is considered to be one of the mechanisms.Middle ear malformation is often accompanied by other abnormalities or dysfunction in syndromes of different phenotypes.In recent years,molecu-lar etiologies of such syndromes have been reported and discussed.In this review,we will discuss the embryonic devel-opment of middle ear and clinical characteristics of related syndromes,focusing on the research progress on their genet-ic etiologies and mechanisms.
Keywords：Middle ear deformityConductive deafnessMolecular etiology
Publication Date：2023-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 728-733 )