Mechanisms of Inner Ear Immune and Inflammation Related to Sensorineural Hearing Loss
SAI Na
HAN Weijiu
Abstract：Sensorineural hearing loss(SNHL)is a common clinical condition resulting from dysfunction in the inner ear.Although several mechanisms have been postulated including ischemia,viral infection/reactivation and microtrauma, little is known about its etiopathology.Immune-mediated inner ear diseases have been described and accepted as part of SNHL pathophysiology,which responds to immunosuppressive therapy.Glucocorticoids are widely used in clinical prac-tice,the possible mechanisms of which include anti-inflammatory effects,although the precise mechanism has not been de-termined.The roles of inner ear immune/inflammatory responses in the pathophysiology of SNHL,and immune and inflam-mation-targeted treatment of SNHL are discussed in this article.In addition,possible interventions modulating immune/in-flammatory factors and immune cells(especially macrophages),as therapeutic targets,to repair the tissue and improve hear-ing in patients with SNHL will be discussed.
Keywords：Sensorineural Hearing LossImmune ResponseInflammatory ResponseMacrophagesCorticosteroids
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 221-226 )