Research Advances on Convergence of Cochlear Implantation with Bone Mesenchymal Stem Cell Transplantation in Therapy of Sensorineural Hearing Loss
YIN Xiaoling
HUO Zirong
YAN Shuang
ZHANG Zhihua
Abstract：Sensorineural hearing loss(SNHL)is a difficult and hot issue in the field of otology.The damage of in-ner ear hair cells and spiral ganglion neurons(SGNs)is one of the major factors leading to SNHL.Treatment or rehabili-tation for sensorineural hearing loss can be achieved with hearing aids or cochlear implants,but none of them can re-store the normal auditory structures and the outcomes are often unsatisfactory.In recent years,some scholars have ques-tioned whether cochlear implants can be combined with stem cell transplantation to improve the efficacy of cochlear im-plants.Bone mesenchymal stem cells(BMSCs)have become a research hotspot in modern biology and medicine in re-cent years due to their high amplification potentials,ease to isolate and culture,low immunogenicity and immunomodu-latory functions.BMSCs have been confirmed by a number of clinical trials to have great potentials for clinical applica-tions in tissue damage repair,such as for myocardial infarction,brain injury,and cartilage and bone damage.In this re-view,we will review the relationship between the number of SGNs and efficacy of cochlear implants and transplantation of BMSCs for SGN regeneration/repair,covering challenges in combining cochlear implantation and stem cell transplan-tation.
Keywords：Sensorineural Hearing Loss(SNHL)Bone Mesenchymal Stem Cells(BMSCs)Cochlear ImplantResearch Advance
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 155-159 )