Base Editing and its Applications in Gene Therapy
TAO Yong
ZHAO Xingle
KANG Wen
WU Hao
Abstract：The improvement of CRISPR/Cas9 gene editing efficiency has promoted its applications in bench and clinic research. However,the efficiency of CRISPR/Cas9 is not sufficient for gene modification.Base editing can con-vert one base pair to another permanently and efficiently,without double strains break.Although base editing was only recently developed,it has gained widespread utilization in gene editing,including in mouse inner ear models.Base edit-ing is an effective tool for inner ear gene therapy.
Keywords：Gene EditingBase EditingGene therapy
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 150-154 )