Cisplatin Ototoxicity Mechanisms and Prevention with Locally Delivered Antioxidant Drugs
YU Dehong
WANG Xueling
CHEN Yuming
WU Hao
Abstract：Cisplatin is a widely used and effective drug for the treatment of various solid tumors.Unfortunately, its severe side-effects have also impacted patients,especially its often bilateral,progressive,irreversible and dose-depen-dent ototoxicity.Current evidence indicates that cisplatin triggers the production of reactive oxygen species(ROS)in tar-get tissues in the inner ear.A large number of agents that protect against cisplatin-induced ototoxicity have been success-fully tested in cell culture and animal models.However,many of them interfere with the therapeutic effects of cisplatin, and therefore are not suitable for systemic administration in clinical practice. Until now, none of them has been ap-proved by the FDA.Consequently,local administration strategies,namely intratympanic administration,have been de-veloped to achieve otoprotection,without reducing the antitumoral effects of cisplatin.This review summarizes the clini-cal and experimental studies of ciaplatin ototoxicity,including details of the molecular mechanisms of action,to gain in-sight for future drug development in this field.
Keywords：CisplatinOtotoxicityAntioxidant DrugsPrevention
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 145-149 )