Ultrastructural Pathological Features of Cystic Vestibular Schwannoma
YAN Shuang
HUO Zirong
YIN Xiaoling
ZHANG Zhihua
Abstract：Objective Experiments were conducted to demonstrate differences of ultrastructural pathological changes and biological characteristics between cystic and solid vestibular schwannoma. Methods Cystic vestibular schwannoma (CVS) specimens collected from 15 patients (study group), as well as specimens of solid vestibular schwannoma(SVS)(control group,n=15)were studied by light microscopy and transmission electron microscopy.The specimens were stained with LC3 monoclonal antibodies to demonstrate expression of autophagy. Results Under the electron microscope,typical autophagosomes were seen in CVS,but not in SVS.The rates of positive LC3 immunohis-tochemistry staining was 13.3%,60.0% and 73.3% in SVS tumor body,CVS tumor body and CVS cyst wall,respective-ly.In SVS,the expression of LC3 was significantly lower than in CVS.Conclusions The regulation of autophagy may play an important role in the cystic degeneration of vestibular schwannoma.
Keywords：Vestibular SchwannomaUltrastructural PathologyAutophagyCystic Degeneration
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 141-144 )