Effects of White Noise Exposure on Hearing in Bama Miniature Pigs and Guinea Pigs
Abstract：Objective To find a more suitable animal model for investigating the noise-induced hearing loss by comparing the effects of 120 dB SPL white noise exposure for three hours on the hearing in bama miniature pigs and guinea pigs. Methods Auditory brainstem response (ABR) in 8 bama miniature pigs and 8 guinea pigs with normal hear-ing was tested before exposure, immediately (P0), 1 day (P1) and 7 days (P7) after exposure. Cochlear specimens were observed using scanning electron microscopy. Results The ABR threshold showed a statistically significant difference between the immediate group and P1 group in guinea pigs, but not in bama miniature pigs. There was a statistically sig-nificant difference between the immediate group and P7 group in bama miniature pigs, but not in guinea pigs. Further-more, the bama miniature pigs showed more severe cochlear hair cell damages than that in guinea pigs. Conclusions The bama miniature pig cochleae are more vulnerable to 120 dB SPL white noise exposure, with more profound hearingloss and more severe pathological changes. The results suggest that bama miniature pig could be a more suitable animal model for noise-induced hearing loss study.
Keywords：White noiseBama miniature pigGuinea pigAnimal modelHair cell
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 83-87 )