Otologic Manifestations as first symptoms in Wegener Granulomatosis

AI Youqin; Li Ziyan; FU Yu; WANG Guojian

doi:10.3969/j.issn.1672-2922.2017.01.013

Abstract：Objective To evaluate the clinical features,diagnosis, treatment, and outcomes of Wegener's granulo-matosis with Otologic Manifestations as first symptoms.Methods We retrospectively reviewed3 cases of Wegener's granulomatosis with Otologic Manifestations as first symptoms,and refer to relevant literatures of 3 cases.We evaluated clinical features, the clinical course ,diagnosis, treatment, and outcomes in all cases. Results In 6 cases, the most first frequently findings were ear fullness ,hearing loss, otalgia,4 cases suffered from facial palsy. All cases were misdiag-nosed as otitis media and given drug and surgical treatment earlily. Diagnosis of Wegener's granulomatosis was made when the patients had clinical findings and positive blood serum markers ANCA or c-ANCA, or when there were typi-cal pathological manifestations. Immunosuppressive therapy and hormone therapy were the main currently treatment op-tions.Conclusions The early otologic manifestations of Wegener's granulomatosis were so atypical that Wegener's granu-lomatosis was misdiagnosed easily ,and the treatment was delayed. ANCA or c-ANCA had high specificity in Wegener's granulomatosis and were helpful to the diagnosis of Wegener's granulomatosis earlily. Early diagnosis and treatment were the key factors of the prognosis of Wegener's granulomatosis, so ENT doctors should strengthen the awareness of Wegener's granulomatosis in the ear performance.