Applications of optogenentics in auditory research
LIU Chen
YU Ning
Abstract：Optogenentics involves genetic coding, features a single-component approach and can modulate selected cells in complex tissues. It has made a profound impact on neuroscience research. As opsins continue to be optimized and di-versified, application of optogenetic tools has been attempted in every field of life science to different organism models. Sound signals are transduced via hair cells in the cochlea, encoded as electric signals by spiral ganglion neurons (SGNs), and eventually transmitted to the auditory center. In individuals with deafness, hearing can be partially restored by electric stimulation of SGNs, although sometimes with poor temporal and intensity resolution. Optical stimulation can be selectively focused, which may greatly improve the resolution of sound coding compared to electric stimulation. This paper reviews ap-plications of optogenentic technology in auditory research and its potentials in future scientific research and clinical utilities.
Keywords：optogenenticsHearing systemspiral ganglion neurons
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 837-840 )