Effects of Simulated Spacecraft Environment on Rat Auditory System and Inner Ear Lymphatic Fluid Volume
ZHANG Chi
WU Wei
HAN Haolun
WANG Gang
WANG Hongnan
DING Ruiying
ZHOU Libin
Abstract：Objective To study the effects of compound factors of weightlessness and noise in space-ship on the auditory system and inner ear lymphatic fluid volume in rats. Methods Twenty two SD rats were randomly selected to be exposed to simulated spaceship noise for 8 weeks (the experimental group, n=12) or to be in the control group (n=10). Auditory brainstem response (ABR) thresholds were tested bilaterally be-fore noise exposure, and at 2 weeks, 4 weeks and 8 weeks after exposure. The inner ear lymphatic fluid vol-ume was calculated using a dedicated software each time ABR thresholds were tested. Results 1. In the exper-imental group, there were significant ABR changes at 4 weeks (P<0.05) and 8 weeks (P<0.01) after expo-sure. 2. In the experimental group, the inner ear lymphatic fluid volume showed no significant change at 2 weeks after exposure (P>0.05), but demonstrated changes at 4 weeks (P<0.05) and 8 weeks (P<0.01) after exposure. In the control group, there was no significant change in the inner ear lymphatic fluid volume. Con-clusions The effects of compound factors of weightlessness and noise in a spaceship can cause damage to the auditory system and lead to expansion in the inner ear fluid volume in SD rats.
Keywords：Simulated weightlessnessNoiseAuditory brainstem responseInner Ear Lymphatic Flu-id Volume
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 278-281 )