Application of adeno-associated virus gene vectors in hereditary non-syndromic sensorineural hearing loss
SHI Xunbei
WU Nan
GUO Weiwei
YANG Shiming
LIN Chang
Abstract：Adeno-associated virus has been used in gene therapies due to its unique gene vector advantages. Large amount of literature has demonstrated successful use of adeno-associated virus carrying various target genes in animal mod-els of hereditary hearing loss with different approaches, to be expressed in hair cells, stria vascularis, support cells, spiral ganglion cells, etc, for the purpose of restoration of morphology and function. This paper summarizes the application of ade-no-associated virus gene vectors in hereditary hearing loss, its advantages, successful experiences and problems in the past, and shares new ideas in its utilities in the future.
Keywords：adeno-associated virushereditary hearing lossgene therapyvectors
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 37-42 )