Establish the standard method of Rongchang pig cochlear implant and preliminary observation of hearing function
CHEN Wei
LIU Riyuan
ZHAGN Liang
JI Fei
GUO Weiwei
REN Lili
LI Jianan
YUAN Shuolong
ZHANG Yue
CHEN Lei
YANG Shiming
Abstract：Objective Establish the standard method of cochlear implant on large mammals–pigs, and observed the changes of ABR&EABR before and after cochlear implants. Methods Six Rongchang pigs, male and female un-limited, 40-45 days, 8~12 kg, were selected from Key Laboratory of Pig Industry Sciences (Ministry of Agriculture), Chongqing Academy of Animal Science. Divided into the normal hearing group (Mitf+/+), and the mutation deafness group (Mitf-/-), each group of three. Cochlear implantation were operated in general anesthesia. ABR&EABR were recorded prior to surgery, immediately finish surgery and 1 week after. Observed the position of electrodes by Skull X-ray. Results Cochlear implant is succeed in six animals, electrode position is good, within the cochlea coiling 1.5~1.75 turns. Cochlear implants immediately, operation side (right), waveform of ABR can’t be recorded. Seven days af-ter the operation, operation side (right), ABR threshold is 100 dB SPL at low frequency, but waveform of ABR can’t be recorded at high frequency still. Cochlear implants immediately and a week later, EABR threshold is 90 CL at normal hearing group (Mitf+/+). It was lower than 190 CL of group of mutation deafness(Mitf-/-). Conclusion Our study show that the methods of cochlear implant at Rongchang pig is really practical, and the EABR test via electrodes im-planted is convenient and feasible. Our study provide the basis for more directly research on cochlear implants in vivo and the physiological or pathological changes of cochlear after cochlear implanted.
Keywords：Cochlear implantRongchang pigABREABR
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 15-20 )