Expression of receptors for advanced glycation end product (RAGE) and nuclear factor-κβ(NF-κβ) in middle ear cholesteatoma
LIAO Jun
LIN Chang
Abstract：Objective To study the roles of NF-κβand RAGE in the pathogenesis of middle ear cholestea-toma. Methods Samples of middle ear cholesteatoma (n=23) and normal external ear canal skin (n=18) were collected during middle ear surgeries. Expression of NF-κβand RAGE was examined by immunohistochemis-try. Results All epithelial cells in cholesteatoma revealed abundant plasma expression of NF-κβand RAGE, significantly higher than that in normal skin (0.442±0.060 vs 0.293±0.047 and 0.175±0.017 vs 0.133±0.013, respectively;p<0.01). There was a weak correlation between NF-κβand RAGE expression in middle ear cho-lesteatoma epithelium tissues (r=0.546, p=0.034). Conclusion NF-κβand RAGE may be important factors in-volved in the occurrence and development of middle ear cholesteatom. The signal pathway of RAGE and NF-κβmay be a new drug target in non-surgical treatment of middle ear cholesteatoma.
Keywords：middle ear cholesteatomaNF-κβRAGE
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 729-733 )