Correlation between presbycusis among ethnic Han people in Harbin and single nuceotide polymorphism of GRHL2
ZHOU Bin
XU Ping
CUI zhongtao
FENG miao
BAI zhigang
MA Xiaonan
LI Tingting
Abstract：Objective To study the correlation between presbycusis among the Han ethnic group in Harbin area and sin-gle-nucleotide polymorphism (SNP) of GRHL2 and determine if there is GRHL2 genetic predisposition to presbycusis. Meth-ods Two hundred and twenty five normal hearing (audiometric thresholds at 25 dB HL or better) ethnic Han people older than 50 years (the control group) and 224 Han people older than 50 years with hearing thresholds greater than 25 dB HL (the study group) in urban or suburban areas of Harbin were included in the study , The Sequenom Mass ARRAY specific SNP gene anal-ysis method was employed to analyze genotype frequency and allele frequency in each group.χ2-test was used in statistical analysis to evaluate differences between groups. Results There was no difference in respect to the distribution of genotypes or alleles between these two groups (P> 0.05) by χ2-test. Distributions of genotypes and alleles of rs10955255 and rs2127034 SNP in both groups attained Hardy-Weinberg balance. Distributions of genotypes and alleles of rs1981361 SNP did not attain Hardy-Weinberg balance in the two groups (P<0.05 byχ2-test). Conclusion There appears to be a correlation between presby-cusis among the Han people in Harbin and the GRHL2 rs1981361 SNP. The GRHL2 gene may be a meaningful gene for re-search on genetic susceptibility to presbycusis. Our results provide the basis for future relevant large-scale multicenter studies.
Keywords：PresbycusisGRHL2single-nucleotide polymorphism
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 529-532 )