Analysis of Deafness Gene in Severe-Profound Hearing Loss Patients in Cangzhou
WANG Hongqin
ZHAO Qun
KONG Xiangjun
LI Hongxia
Abstract：[Obstract]Objective To investigate the deafness gene mutations of severe-profound hearing loss in Cangzhou. Methods The hearing loss evaluation,etiologic survey and the molecular genetic analysis of common genes responsible for deafness were performed in 241 hearing impairment students at the special education school in Cangzhou. Results Firstly, 39(16.2%) people were detected to carry deafness genes. Secondly, in the 39 subjects, 25(10.4%)people were found to carry GJB2 mutation. 12 peo?ple were detected 235delc homozygous mutation. One person was 299delAT homozygous mutation. 6 ones were detected 235delc single heterozygous mutation and 6 people were compound heterozygous mutation. Thirdly, only one person(0.41%) was found to carry GJB3 mutation. Finally, there were 14 subjects(5.8%)with SLC26A4 mutation. 3 people were foundⅣS7-2A>G homozy?gous mutation, 10 people were foundⅣS7-2A>G single heterozygous mutation, and one person was compound heterozygous muta?tion. Conclusions The incidence of hereditary deafness is high at the special education school in Cangzhou, and through the deaf?ness gene examination, we can know the causes of deafness to prevent the deafness and to evaluate the prognosis of hearing loss.
Keywords：DeafnessGeneScreening
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 326-328 )