Prevalence and Clinical Outcome of Auditory Neuropathy Spectrum Disorder (ANSD) in Newborn Hearing Screening
WANG Hongyang
LI Qian
DING Haina
WANG Hui
XIE Linyi
ZHENG Longyan
SHI Wei
YU Lan
LAN Lan
HAN Bing
WANG Dayong
GUAN Jing
WANG Qiuju
Abstract：Objective To analyze the prevalence of auditory neuropathy spectrum disorder (ANSD) in Chinese new-borns hearing screening and the related factors, and to analyze the clinical outcomes of ANSD in newborns. Methods Be-tween December 2003 to November 2013, 5134 newborns in Chinese PLA general hospital were recruited. DPOAE was screened in the first step, and the DPOAE plus AABR was screened in the second step screening. The prevalence of ANSD and the related factors were analyzed, as well as the correlation analysis between various factors and ANSD. Results:Among the ascertained newborns, 8 had normal DPOAE and abnormal or deficient ABR results, which were consistent with ANSD. The prevalence of ANSD in newborns was 0.156%. 1) The ratio of unilateral and bilateral ANSD was 3:1, the ratio of male to female was 3:1, and the prevalence of ANSD among eutocia newborns and cesarean section newborns were 0.135% and 0.171%, respectively. There were no significant difference between different gender and different childbirth way (P>0.05);2) The prevalence of ANSD among the DPOAE pass and refer cases in the first screening were 0.160%and 10.127%, respectively, the difference of which had statistical significance. The prevalence of ANSD among the AABR pass and refer cases in the second screening step were 0.087%and 0.765%, respectively, which had significant difference;DPOAE refer in the first step and AABR refer in the second step were risk factors for neonatal ANSD;3) Only one of the 8 babies had risk factors, which had no significant correlation with ANSD. Only one of the eight newborn ANSD was diagnosed as ANSD after diagnostic audiological detection. Conclusion 1) DPOAE refer in the first step and AABR refer in the second step were risk factors for neonatal ANSD;2) In this study, the data can not prove that the history of NICU hospitalization, premature birth and hyperbilirubinemia are the risk factors for neonatal ANSD;3) Newborn ANSD has the temporary charac-ter, which is hard to estimate prognosis, needing close follow-up.
Keywords：NewbornHearing screeningAuditory neuropathy spectrum disorderPrevalenceClinical outcome
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 206-212 )