Neurod1 in the Development of Inner Ear Sensory Neurons and Hair Cells
WANG Chunmei
QING Jie
XIE Dinghua
Abstract：This article focuses on the research on Neurod1’s roles in the development of sensory neurons and hair cells in the inner ear. Neurod1 is an important member of the bHLH transcription factors family. It promotes differentiation of neuro?nal precursor cells into neurons. In the inner ear, Neurod1 is mainly expressed on sensory neurons and part of the sensory epi?thelium. Conditional Neurod1 knockout mice exhibit hearing and balance disorders, with significant loss of sensory neurons in the inner ear and defects of both afferent and efferent nerves. Ectopic hair cells can also appear in the spiral ganglion in condi?tional Neurod1 knockout mice. In the process of inner ear development, Neurod1 interacts with multiple genes including Neu?rog1, Atoh1, Sox2 and Nhlh1.
Keywords：Neurod1Sensory neuronHair cell
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 161-165 )