Detection of Guinea Pigs’Hearing Functions before and after White Noise Exposure
ZHANG Jishuai
CHEN Xingrui
WU Jun
HAN Weiju
Abstract：Objective Using different techniques to detect guinea pigs’hearing functions before and after white noise exposure,to study the effects of 120 dB SPL white noise on hearing in guinea pigs, as an animal model for hearing research in guinea pigs. Methods In the noise exposure condition of 120 dBSPL white noise, to compare the auditory brainstem response (ABR), distortion product otoacoustic emission (DPOAE) and electrically evoked auditory brainstem response (eABR) were compared between 20 guinea pigs exposed to white noise at 120 dB SPL and 20 normal control guinea pigs. Results ABR thresholds, DPOAE amplitudes and eABR thresholds were significantly different between the noise exposed guinea pigs and normal control guinea pigs (p<0.05). Conclusion White noise at 120 dB SPL can consistently induced hearing loss in guin?ea pigs, which can serve as an animal model for studying hearing and hearing loss.
Keywords：Guinea pigNoise-induced hearing lossABRDPOAEeABR
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 141-144 )