Prospects of Application of Cationic Polymer Nanoparticle Gene Vectors in Inner Ear
WANG Fangyuan
WU Nan
CHEN Zhengyi
YANG Shiming
Abstract：Due to the unique anatomical and physiological features of the cochlea, systemic drug/gene therapy is diffi?cult to achieve effective local concentrations in the inner ear. Therefore,research on local drug/gene in the inner ear has be?come a new hotspot. Selecting an appropriate vector for local drug/gene therapy is the key point. Compared with virus vec?tor, polymer nanoparticle vector has the advantages of carrying low toxicity and no immunogenicity, and being easy to modify and acquire with high transporting capability, making it a improved option as a vector for drug/gene delivery to the inner ear. This paper summarizes the characteristics of cationic polymers and their superiority as drug/gene vector. Furthermore, it al?so reviews the application of cationic polymers in the inner ear, and provides guidance for potential transition towards drug/gene therapies bb for inner ear disorders.
Keywords：Hearing lossCationic polymersNnanoparticle vector
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 92-96 )