Sodium Salicylate Reversibly Suppresses GABA-induced Currents in Spiral Ganglion Neurons in Rats
CAI Zheng
YAO Chen
CHEN Huiying
HUANG Zhihui
QIN Jixin
SU Jiping
Abstract：Objective To study the effect of sodium salicylate (SS) on the function of GABAa receptors in spiral gangli?on neurons (SGNs). Methods GABAa receptor currents were recorded using whole-cell patch clamp techniques in isolated SGNs. The effects of SS were characterized. Results The currents evoked by GABA in SGNs were blocked by 10μM bicucul?line. No detectable currents were recorded upon using SS at 0.5 mM, 0.1 mM or 5 mM. Various degrees of reversible suppres?sions of GABA-induced currents were observed by administrating GABA (100μM or 500μM) combined with SS. Conclu?sion GABAa receptors currents can be recorded in rat cochlea SGNs. SS reversibly attenuates GABAa receptors response in SGNs. The effects are dose-dependent with both GABA and SS.
Keywords：Sodium salicylateGABAa receptorSpiral ganglion neuronsWhole-cell patch-clamp
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 87-91 )