Study on the Expression of Synaptic Endocytosis Key Protein Dynamin in Mice Cochlear Inner Hair Cells
CAI Ting
YUAN Wei
Abstract：Objective To study expression and distribution characteristics of each subtype of Dynamin in mice inner hair cell (IHC) and its possible roles in the physiological function of inner hair cells as well as laying the groundwork for study?ing its relationship with hearing. Methods Expression and distribution of each subtype of Dynamin in cochlear basement mem?brane of adult mice were distinguished by immunefluorescent, and examined by laser confocal microscope. Results Various subtypes of Dynamin were detected in the inner hair cell of mice. Of which, Dynamin-1 was seen in the entire inner hair cell, Dnamin-2 in the cytoplasm, and Dynamin-3 highly expressed under the nucleus of inner hair cells close to the spiral ganglion. Conclusion Clathrin mediated endocytosis is a major pathway of vesicle recycling, in which, Dynamin plays an important role. Various subtypes of Dynamin are expressed in the cochlear hair cells, indicating that Dynamin may have an important physio?logical function in inner hair cells.
Keywords：Inner hair cellEndocytosisImmunofluorescenceDynamin
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 643-646 )