A Characteristics Comparison of Auditory Brainstem Response on Minipig and Human
XIE Yafang
MA Long
ZHAO Lidong
CONG Tao
YU Ning
LIU Ke
YANG Shiming
LIN Chang
Abstract：Objective to analysis the auditory brainstem response(ABR)wave characteristics of normal-hearing mini-pig, and compare with the human. Methods 15 normal-hearing minipigs to be selected and tested by click and tone burst stim-ulus respectively in P10、P30 and P60, and record the datas. Results①Minipig can differentiate 7 waves, of which the waveⅤis the most distinguished and the symbol of threshold, the value of which is 25-30dB SPL , and auditometry frequencies ranges from 1 to 48 kHz of which the most sensitive frequency is 2kHz;②the minipig’s ABR latencies of waveⅠ、Ⅱ、Ⅳ、Ⅴand interpeak latency ofⅡ-Ⅴare separately 1.53 ± 0.18、2.60 ± 0.16、3.36 ± 0.22、4.76 ± 0.21、2.16 ± 0.14(ms)in P10, 1.68 ± 0.23、2.79±0.33、3.47±0.32、4.97±0.32、2.17±0.30(ms)in P30, and 1.71±0.22、2.74±0.23、3.45±0.25、4.82±0.22、2.08±0.23 (ms)in P60;both latencies of P30、P60 are longer than the P10, but the latency of P60 is shorter than P30;and there’s a sig-nificant difference between P10 and P30, but not between P10 and P60;③the ABR latency and amplitude of miniature pig’s between bilateral ears are slight differences, which also have no significance. Conclusions the ABR waves of minipig are simi-lar to human, and may derive from the same resources;hence, we can take advantage of animal models of human’s disease by use of minipig.
Keywords：MinipigAauditory brainstem responseTthresholdAmplitudeLatency
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 485-489 )